1. You installed Acronis Backup 12.5 Update 4 (build 13400 and higher),
2. When you navigate to Settings -> Agents -> Details, you see that Agent is shown offline since year 1754 (exact date depends on your environment). You cannot run a backup plan on this machine or apply new backup plans to it.
Cause
Issue in the product.
Acronis Development team is working on fixing this issue in next version of Acronis Backup 12.5.